CD40L stimulation enhances the ability of conventional metaphase cytogenetics to detect chromosome aberrations in B-cell chronic lymphocytic leukaemia cells
نویسندگان
چکیده
منابع مشابه
Nonrandom chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation.
Peripheral blood lymphocytes from 11 patients with chronic lymphocytic leukemia were stimulated by Epstein-Barr virus (EBV), lipopolysaccharide from Escherichia (LPS), and phytohemagglutinin (PHA). Chromosome analysis with the Q-banding technique after 5 days incubation revealed an extra chromosome 12 in 5 of the patients and a translocation between chromosome 11 and chromosome 14 in 1. Two pat...
متن کاملT-cell CD38 expression in B-chronic lymphocytic leukaemia.
B-cell chronic lymphocytic leukaemia (B-CLL) is a heterogeneous disease with some patients having an indolent course never needs treatment, while others having rapidly progressive one requires intensive treatment. In recent decades, numerous prognostic markers, such as immunoglobulin variable region heavy-chain (IgVH) mutational status, ZAP-70 and the expression of CD38 on leukaemic cells were ...
متن کاملThe assessment of caspase activation during apoptosis of malignant cells in B-cell chronic lymphocytic leukaemia
In this study we analysed caspase activation in peripheral blood and bone marrow cells of B-cell chronic lymphocytic leukaemia (B-CLL) exposed to apoptosis both spontaneous and induced via external and internal pathway. We used the method based on detection of activated caspases with FAM-VADFMK that is the fluorochrome labelled inhibitor of caspases and flow cytometry technique. We detected the...
متن کاملCutaneous B-cell chronic lymphocytic leukaemia resembling a granulomatous rosacea.
B-cell chronic lymphocytic leukemia (B-CLL) is a low-grade lymphoproliferative disease. Cutaneous involvement of B-CLL is limited and, in most cases, it represents non-specific manifestations related to an impaired immune system. Leukemic skin infiltrates (leukemia cutis) occur in 4-20% of patients. Herein we report the case of a 65-year-old woman with B-CLL presenting with papular, nodular, an...
متن کاملEngineered T Cells for the Adoptive Therapy of B-Cell Chronic Lymphocytic Leukaemia
B-cell chronic lymphocytic leukaemia (B-CLL) remains an incurable disease due to the high risk of relapse, even after complete remission, raising the need to control and eliminate residual tumor cells in long term. Adoptive T cell therapy with genetically engineered specificity is thought to fulfil expectations, and clinical trials for the treatment of CLL are initiated. Cytolytic T cells from ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2002
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2002.03719.x